Discovery of De Novo Macrocyclic Peptides by Messenger RNA Display
نویسندگان
چکیده
Macrocyclic peptides are a promising class of compounds that can often engage challenging therapeutic targets. Display technologies, such as mRNA display, allow for the efficient discovery macrocyclic peptides. This article reviews current approaches generating peptide libraries using display and highlights some recent examples ribosomal incorporation nonproteinogenic amino acids into
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ژورنال
عنوان ژورنال: Trends in Pharmacological Sciences
سال: 2021
ISSN: ['0165-6147', '1873-3735']
DOI: https://doi.org/10.1016/j.tips.2021.02.004